毛朝明

 
出生年月
1969年6月生
 
研究领域
临床免疫学(肿瘤免疫、自身免疫)
 
主讲课程
 
个人简介

毛朝明,男,汉族,1969年6月生,江苏丹阳人,医学博士,副教授,副主任技师,硕士生导师。上海交通大学免疫学专业毕业。现任江苏大学肿瘤研究院实验室主任,附属医院肿瘤生物治疗中心主任,附属医院核医学科主任,江苏大学临床医学院核医学教研室主任,镇江市免疫学重点实验室副主任,江苏省医学会核医学专业委员会委员。现发表SCI研究论文25篇。

 
学术简介

 
主要科研项目成果

在研课题(截至2013年底):
项目来源 类别 编号 名称 研究起止年月 获资助金额 本人作用 状态
国家自然基金 基础研究 81370889 甲状腺上皮—免疫细胞转分化及其自噬改变在自身免疫性甲状腺疾病中的作用研究 2014.01- 2017.12 140万元 负责 正在进行
省自然基金 基础研究 BK20131248 甲状腺EIT诱导自噬改变在AITD中的作用研究 2013.08-
2016.08 21万元 负责 正在进行
市级自然基金 应用研究 SH2011019 血清AITRL/ULBP3方法学建立及对大肠癌诊断价值研究 2011.12-2013.12 8万元 负责 正在进行
市级自然基金 应用研究 SH2013031 UL16结合蛋白对胃癌早期诊断价值的研究 2013.08-
2015. 08 10万元 负责 正在进行
省自然基金 基础研究 BK20131245 IncRNA H19调控Th17诱导上皮-免疫细胞转分化在食管癌免疫逃逸中的作用研究 2013.08-
2016.08 20万元 第二责任人 正在进行

 
主要论著

代表性论文:
[1] Mao C, Wang S, Xiao Y, Xu J, Jiang Q, Jin M, Jiang X, Guo H, Ning G, Zhang Y. Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. The Journal of Immunology, 186(8): 4734-4743. 2011
[2] Mao C*, Mou X, Zhou Y, Yuan G, Xu C, Liu H, Zheng T, Tong J, Wang S, Chen D. Tumor-activated TCRγδ+ T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRαβ+ T Cells via their Antigen-presenting Cell-like Effects. J Immunol Res, 2014:593562. 2014 (兼通讯作者)
[3] Deyu Chen, Zhaoyue Zhang, Chaoming Mao*, Yuepeng Zhou, Lichao Yuc, Yue Yina, Shi Wua, Xiao Moua, Yan Zhub. ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma. Cellular Immunol, 289: 91-96.2014 (通讯作者)
[4] Mao C*, Qin W, Chen D, Yuan G, Mou X, Bao D, Wu W, Xu H, Wang S. A monoclonal antibody against human UL16-binding protein 3. Hybridoma (Larchmt), 31(3): 203-208. 2012(兼通讯作者)
[5] Chen Deyu, Jiang R, Mao C*, Shi L, Wang S, Yu L, Hu Q, Dai D, Xu H. Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma. Hum Immunol, 73(11): 1068-1072. 2012(通讯作者)
[6] Chen D, Hu Q, Mao C, Jiao Z, Wang S, Yu L, Xu Y, Dai D, Yin L, Xu H. Increased IL-17- producing CD4(+) T cells in patients with esophageal cancer. Cell Immunol, 272(2): 166-174. 2012
[7] Xiao Y, Xu J, Mao C, Jin M, Wu Q, Zou J, Gu Q, Zhang Y, Zhang Y. 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha. J Biol Chem, 285(2): 1128-1137. 2010
[8] Xiao Y, Xu J, Wang S, Mao C, Jin M, Ning G, Xu J, Zhang Y. Genetic ablation of steroid receptor coactivator-3 promotes PPAR-beta-mediated alternative activation of microglia in experimental autoimmune encephalomyelitis. Glia, 58(8): 932-942. 2010
[9] Ma J, Wang S, Ma B, Mao C, Tong J, Yang M, Wu C, Jiao Z, Lu L, Xu H. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Lett, 301(2): 142-150. 2011
[10] Wang S, Shi Y, Yang M, Ma J, Tian J, Chen J, Mao C, Jiao Z, Ko KH, Baidoo SE, Xu H, Hua Z, Lu L. Glucocorticoid-induced tumor necrosis factor receptor family-related protein exacerbates collagen-induced arthritis by enhancing the expansion of Th17 cells. Am J Pathol, 180(3): 1059-1067. 2012
[11] Cai M, Zhou T, Li X, Chen J, Mao C, Xi X, Chen N, Xu C. DC-SIGN modulates DC maturation and function in rat renal tubulointerstitial lesions. Front Biosci, 17: 1795-1803. 2012
[12] Gu Q, Wu Q, Jin M, Xiao Y, Xu J, Mao C, Zhao F, Zhang Y, Zhang Y. Heme oxygenase-1 alleviates mouse hepatic failure through suppression of adaptive immune responses. J Pharmacol Exp Ther, 340(1): 2-10. 2012
[13] Tian J, Ma J, Wang S, Yan J, Chen J, Tong J, Wu C, Liu Y, Ma B, Mao C, Jiao Z, Shao Q, Lu L, Xu H. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cell Immunol, 270(2): 183-187. 2011
[14] Yuan Guoyue, Jia J, Di L, Zhou L, Dong S, Ye J, Wang D, Yang L, Wang J, Li L, Yang Y, Mao C, Chen M. Effects of C-reactive protein on adipokines genes expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun, 424(3): 462-468. 2012
[15] Ma J, Zhu C, Ma B, Tian J, Baidoo SE, Mao C, Wu W, Chen J, Tong J, Yang M, Jiao Z, Xu H, Lu L, Wang S. Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clin Dev Immunol, 2012: 827480. 2012

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