郑其平

 
出生年月
1965.11
 
研究领域
软骨发育成熟特异的十型胶原蛋白基因(Col10a1)的分子调控;多种转录因子(RUNX2, P53/P63, Cox-2等)与骨骼发育,病变,骨关节炎及骨肉瘤发生的相关性研究。
 
主讲课程
 
个人简介

郑其平,1965年11月生,理学博士,江苏大学教授,硕士生导师,1982-1987年就读于安徽医科大学医疗系,获医学学士学位。1987-1990年于苏州医学院攻读硕士研究生获硕士学位。1990-1995年,于南京市脑科医院神经与精神科从事临床与实验研究工作。1995-1998年在复旦大学遗传所攻读遗传学并获理学博士学位。1999-2004年于美国休斯敦市贝勒医学院的人类与分子遗传学系从事博士后研究。2004-2007年被贝勒医学院人类与分子遗传系聘任为研究助理教授。2007-2012任拉什大学医学中心解剖与细胞生物系助理教授。2012年6月任江苏大学(特聘)教授。

 
学术简介

郑其平博士人多年来致力于人类基因组、十型胶原蛋白基因调控、转基因实验动物模型构建与骨骼生长、发育,以及骨关节炎、骨肿瘤等疾病发生机制的研究,取得了一批成果。具体体现在:1)在骨与生物学研究领域发表了数十篇高水平的论文;论文被他引总计近200 次并涉及了多种生物遗传的重要杂志,如细胞生物学(JCB)、美国人类遗传学(AJHG)、美国国家科学院(PNAS)、骨与矿物研究(JBMR)、生物化学(JBC)、细胞生理学(JCP)以及基因(Gene)等杂志。2)研究成果得到美国关节炎基金会的肯定和奖励,并于2006年成为全美四位关节炎研究获奖学者之一。3)先后被世界著名的贝勒医学院和享誉美国中西部的拉什大学医学中心聘任为助理教授并拥有自己独立的实验室。 4)在美国工作期间主持7项并参与了2项包括美国国立卫生研究院(NIH),美国关节炎和肿瘤基金会以及在内的多项研究课题。研究经费总额达400万美元,其中主持经费超过200万美元($2, 046,553)。5)为国际学术组织骨科协会,骨与矿物质研究协会会员,在国际重要学术会议上作大会报告7次。6)为拉什大学医学中心动物保护与应用委员会会员(Institutional Animal Care and Use Committees, IACUC)。参与审阅实验动物应用申请报告。7)2012年6月,郑其平博士被江苏大学聘任为特聘教授。当年即成功地主持申请了2012年度国家自然科学基金面上项目和国家级大学生创新计划项目,同时郑博士还受邀参与国家自然科学基金项目的审阅。 8)郑其平博士参与下列英文杂志:International Journal of Biological Sciences,J Biological Chemistry, J Cell Sci, Molecular Genetics and Genomics, J Bone Material Res-A, Therapeutic Advances in Musculoskeletal Disease, and Molecular Carcinogenesis的文稿的审阅。2013年4月被American Journal of Cancer Research聘任为编辑。

 
主要科研项目成果

1)课题名称:Determinants of type X collagen gene expression during chondrocyte hypertrophy
资金来源:Arthritis Foundation Postdoctoral Fellowship
项目金额与年限: $105,000,three years (2001-2004)
2)课题名称: Mouse Col10a1 gene regulation and skeletal development
资金来源: NIH/NIDCR (R03), DE16041-02
项目金额与年限: $150,500,two years (2004-2006)
3)课题名称: Identification of transcriptional determinants for mouse Col10a1 expression
资金来源: Arthritis Foundation Arthritis Investigator Award
项目金额与年限: $330,000,four years (2006-2010)
4)课题名称: P63 in bone development and cancer formation
资金来源: Rush Pilot Project
项目金额与年限: $150,000,two years (2008-2010)
5)课题名称: Chondrocyte maturation and osteosarcoma
资金来源: Bear Necessities Pediatrics Cancer Foundation
项目金额与年限: $20,000, one year (2010-2011)
6)课题名称: Osteosarcoma translational research
资金来源: NIH/NCI (R21), 1R21CA161461-01A1
项目金额与年限: $366,053,two years (2012-2014)
7)课题名称: In vivo function of Runx2 on murine osteosarcoma development
资金来源: American Cancer Society-Illinois Division
项目金额与年限: $100,000,one year (2013-2014)
8)课题/经费名称:科研启动研究经费
资金来源:拉什大学医学中心征聘人员启动资金(见拉什大学聘用书)
项目金额与年限: $825,000, Three years (2007-2010)
9)课题名称: 颌面部骨骼疾病十型胶原蛋白基因 的异常调控
资金来源: 国家自然科学基金面上项目
项目金额与年限: 70万/4年 (2013-2016)
10)课题名称:RMP是潜在的宫颈癌生物标志物吗?
资金来源: 国家教育部大学生创新创业训练计划项目
项目金额与年限:2万/1年 (2013-2014)

 
主要论著

1. Gu J, Li, X., Liang, Y., Qiao, L., Ran, D., Lu, Y., Li, X., Wei, W, and Zheng, Q. (2013). Upregulation of URI/RMP gene expression in cervical cancer by high-throughput tissue microarray analysis. Int J Clin Exp Pathol 2013;6(4):669-677 www.ijcep.com /ISSN:1936-2625 / IJCEP1302019, (Corresponding author).
2. Lu Y, Abassi S, Li F, Ding, M, Wu G, Gu J, and Zheng, Q. (2013). Distinct function of P63 isoforms during embryonic skeletal development. Gene Feb 26; 519(2):251-259 (2013), doi: 10.1016/j.gene.2013.02.021. [Epub ahead of print] (Corresponding author).
3. Ding, M., Lu, Y., Abbassi, S., Sumner, D., Li, F., Song, Y., Geoffroy, V., and Zheng, Q., (2012). Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol. 2012 Oct;227(10):3446-56. doi: 10.1002/jcp.24045. (Corresponding author).
4. Li, F., Lu, Y., Ding, M., Wu, G, Sinha, S., Wang, S., and Zheng, Q. (2012). Putative function of TAP63α during endochondral bone formation. Gene Mar 10; 495(2):95-103 (2012), doi:10.1016/j.gene.2011.12.057. (Corresponding author).
5. Li, F., Lu, Y., Ding, M., Napierala, D., Abbassi, S., Chen, Y., Duan, X., Wang, S., Lee, B., and Zheng, Q. (2011). Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer. J Bone Miner Res. 26(12):2899-2910. (Corresponding author).
6. Yang, H., Gu, J., Zheng, Q., Li, M., Lian, X., Miao, J., Jiang, J., and Wei, W. (2011). RPB5-Mediating Protein (RMP) is required for the proliferation of hepatocellular carcinoma cells. J Biol. Chem. 286(13):11865-74.
7. Li, F; Jiang, Y; Zheng, Q ; Yang, X; and Wang, S. (2011). TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Biochem Biophys Res Commun. 404(1):79-85.
8. Gu, J., Sun, D., Zheng, Q., Wang, X., Yang, H., Miao, J., Jiang, J., and Wei, W. (2009). Human Elongator complex is involved in cell cycle and suppresses cell growth in 293 T human embryonic kidney cells. Acta Biochim Biophys Sinica. 41(10):831-8.
9. Zheng, Q., Keller, B., Zhou, G., Napierala, D., Chen, Y., Zabel, B., Parker, A., and Lee, B (2009). Localization of the cis-enhancer element for mouse type X collagen gene expression in hypertrophic chondrocytes in vivo. J Bone Miner Res. 24(6):1022-1032 (Corresponding author).
10. Napierala, D., Sam, K., Morello, R., Zheng, Q., Munivez, E., Shivdasani, RA., and Lee, B (2008). Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 17(14):2244-54.
11. Zhou, G., Zheng, Q., Engin, F., Munimez, E., Chen, Y., Sebald, E., Krakow, D., and Lee, B. (2006). Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci USA. 103(50):19004-9.
12. Napierala, D., Garcia-Rojas, X., Sam, K., Wakui, K., Chen, C., Mendoza-Londono, R., Zhou, G., Zheng, Q., and Lee, B. (2005). Mutations and Promoter SNPs in RUNX2, a Transcriptional Regulator of Bone Formation. Mol Genet Metab 86(1-2): 257-68.
13. Zheng, Q., Sebald, E., Zhou, G., Chen, Y., Wilcox, W., Lee, B., and Krakow, D. (2005). Dysregulation of Chondrogenesis in Human Cleidocranial Dysplasia. Am J Hum Genet 77(2):305-12.
14. Zheng, Q., Zhou, G., Morello, R., Chen, Y., Garcia-Rojas, X., and Lee, B. (2003). Type X Collagen Gene Regulation by RUNX2 Contributes Directly to Its Hypertrophic Chondrocyte-specific Expression In Vivo. J Cell Biol. 162 (5): 833-842.
15. Scaglia, F., Zheng, Q., O’Brien, W.E., Henry, J., Rosenberger, J., Reed, P., and Lee, B. (2002). An Integrated Approach to the Diagnosis and Prospective Management of Partial Ornithine Transcarbamylase Deficiency. Pediatrics 2002 Jan; 109(1): 150-2.
16. Zheng, Q., Yu, L., Zhao, Y., Zhang, H., Fu, Q., Mao, N., Hu, P., Geng, Z., and Zhao, S. (2001). Structure Characterization of Human RalGDS Gene, and the Identification of Its Novel Variant Molecular Biology Report 27(4):209-16.

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