王胜军

 
出生年月
 
研究领域
免疫调节与自身免疫性疾病、肿瘤免疫学诊断及治疗
 
主讲课程
医学检验、临床医学、医学影像、医学护理、药学、临床免疫学和免疫检验、医学免疫学、免疫学进展
 
个人简介

王胜军:男,博士,教授,博士生导师。现任江苏大学基础医学与医学技术学院副院长,检验医学研究所执行所长,兼任中华医学会微生物免疫学会青年委员、江苏省免疫学会理事、江苏省医学微生物与免疫学会委员、Member of American Association of Immunologists等。先后入选江苏省高校中青年学术带头人,江苏省高校优秀青年骨干教师,江苏大学“拔尖人才工程”培养对象。

 
学术简介

科研方向主要集中在免疫调节与自身免疫性疾病、树突状细胞生物学功能以及肿瘤免疫学治疗等方面。作为课题负责人主持国家自然科学基金4项、国家自然科学基金国际交流合作项目2项、江苏省自然科学基金(创新人才项目)和社会发展项目等课题9项,参加国家自然科学基金3项,国家"863"子课题1项。先后在Am J Pathol、J Clin Endocrinol Metab等国内外期刊发表研究论文180篇(其中SCI收录40篇),主持和参加的科研成果有10项通过省市科技鉴定,获省部级科技进步奖3项、市厅级科技进步奖8项,申请国家发明专利5项,授权1项。

 
主要科研项目成果

1 beta-葡聚糖促进髓源性抑制细胞分化作用及其机制研究,国家自然科学基金(31170849),项目负责人
2 GITRL在小鼠胶原诱导性关节炎发生中的作用及其机制研究,国家自然科学基金(81072453),项目负责人
3瘦素诱导Th17细胞分化的分子机制及在EAT疾病发生中的作用,国家自然科学基金(30871193),项目负责人
4基因修饰DC诱导的调节性T细胞及对EAT治疗作用的研究,国家自然科学基金(30300169),项目负责人
5 Foxp3基因转染DC的分子机制研究,国家自然科学基金国际合作(30610103127),项目负责人
6瘦素诱导Th17细胞分化的体内研究,国家自然科学基金国际合作(30910103087),项目负责人
7 GITRL阻断Treg细胞免疫抑制功能的实验研究,江苏省自然科学基金-创新人才学科带头人项目(BK2004405),项目负责人
8 T细胞疫苗治疗自身免疫性甲状腺炎的研究,江苏省社会发展科技计划项目(BS2000026),项目负责人

 
主要论著

1 Shengjun Wang (王胜军,通讯作者), Ye Shi, Min Yang, Jie Ma, Jie Tian, Jianguo Chen, Chaoming Mao, Zhijun Jiao, King-Hung Ko, Samuel Essien Baidoo, Huaxi Xu, Zichun Hua, Liwei Lu .GITRL exacerbates collagen-induced arthritis via enhancing the expansion of Th17 cells,Am J Pathol. 2012 Mar;180(3):1059-67. (SCI IF 5.224)

2 Chenlu Zhu, Jie Ma, Yingzhao Liu, Jia Tong, Jie Tian, Jianguo Chen, Xinyi Tang, Huaxi Xu, Liwei Lu, Shengjun Wang (王胜军,通讯作者). Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease, J Clin Endocrinol Metab. 2012 Mar;97(3):943-50. (SCI IF 6.495)

3 Jie Tian, Jie Ma, Ke Ma, Bin Ma, Xinyi Tang, Samuel Essien Baidoo, Jia Tong, Jun Yan, Liwei Lu, Huaxi Xu, Shengjun Wang (王胜军,通讯作者). Up-regulation of GITRL on Dendritic Cells by WGP Improves Anti-tumor Immunity in Murine Lewis Lung Carcinoma. PLOS ONE, 2012, PLoS ONE; 2012, 7(10): e46936 (SCI IF 4.092)

4 Shengjun Wang (王胜军,通讯作者), Samuel Essien Baidoo, Yingzhao Liu, Chenlu Zhu, Jie Tian, Jie Ma, Jia Tong, Jianguo Chen, Xinyi Tang, Huaxi Xu and Liwei Lu. T cell-derived leptin contributes to increased frequency of Th17 cells in female patients with Hashimoto's thyroiditis. Clin Exp Immunol,online: 27 AUG 2012, DOI: 10.1111/j.1365-2249.2012.04670.x (SCI IF 3.360)

5 Chen J, Tong J, Liu H, Liu Y, Su Z, Wang S (王胜军,通讯作者), Shi Y, Zheng D, Sandoghchian S, Geng J, Xu H. Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71. J Med Virol. 2012 May;84(5):763-7. (SCI IF2.895)

6 Jie Ma, Chenlu Zhu, Bin Ma, Jie Tian, Samuel Essien Baidoo, Chaoming Mao, Wei Wu, Jianguo Chen, Jia Tong, Min Yang, Zhijun Jiao, Huaxi Xu, Liwei Lu, and Shengjun Wang (王胜军,通讯作者). Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid Arthritis, Clin Dev Immunol, 2012 Volume (2012), Article ID 827480 (SCI IF2.263)

7 Mao C, Qin W, Chen D, Yuan G, Mou X, Bao D, Wu W, Xu H, Wang S (王胜军,通讯作者).A monoclonal antibody against human UL16-binding protein 3. Hybridoma (Larchmt). 2012 Jun;31(3):203-8. (SCI IF 0.417)

8 Shotorbani SS, He Z, Yang H, Sun Q, Xu Y, Su Z, Xue Y, Zheng D, Zhang Y, Wang S(王胜军), Shao Q, Lu L,Xu H. Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation. Cell Immunol. 2012 Jan;275(1-2):61-8. (SCI IF 2.575)

9 Liu Y, Zhu H, Su Z, Sun C, Yin J, Yuan H, Sandoghchian S, Jiao Z, Wang S(王胜军), Xu H. IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKCβ/Erk1/2/NF-κB-dependent signaling pathway. Int Immunol. 2012 Apr 24,PMID: 22531062 (SCI IF3.301)

10 Chen D, Hu Q, Mao C, Jiao Z, Wang S(王胜军), Yu L, Xu Y, Dai D, Yin L, Xu H. Increased IL-17-producing CD4(+) T cells in patients with esophageal cancer.Cell Immunol. 2012;272(2):166-74.

11 Qingzhen H, Jia T, Shengjun W(王胜军), Yang Z, Yanfang L, Pei S, Essien BS, Zhaoliang S, Sheng X, Qixiang S, Finegold SM, Xu H.Corynebacterium pyruviciproducens promotes the production of ovalbumin specific antibody via stimulating dendritic cell differentiation and up-regulating Th2 biased immune response. Vaccine. 2012 Feb 1;30(6):1115-23. (SCI IF3.572)

12 Shi Y, Sandoghchian Shotorbani S, Su Z, Liu Y, Tong J, Zheng D, Chen J, Liu Y, Xu Y, Jiao Z, Wang S(王胜军), Lu L, Huang X, Xu H. Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. Clin Dev Immunol. 2012;2012:295081. (SCI IF2.263)

13Yang M, Deng J, Liu Y, Ko KH, Wang X, Jiao Z, Wang S(王胜军), Hua Z, Sun L, Srivastava G, Lau CS, Cao X, Lu L. IL-10-Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation. Am J Pathol. Am J Pathol. 2012 Jun;180(6):2375-85. (SCI IF 5.224)
14 Chen D, Jiang R, Mao C, Shi L, Wang S(王胜军), Yu L, Hu Q, Dai D, Xu H. Chemokine/chemokine receptor interactions contribute to the accumulation of Th17 cells in patients with esophageal squamous cell carcinoma. Hum Immunol. 2012 Jul 31. [Epub ahead of print]PMID: 22863447 (SCI IF 2.837)
15 He Z, Shotorbani SS, Jiao Z, Su Z, Tong J, Liu Y, Shen P, Ma J, Gao J, Wang T, Xia S, Shao Q, Wang S(王胜军), Xu H. HMGB1 promotes the differentiation of Th17 via up-regulating TLR2 and IL-23 of CD14(+) monocytes from patients with rheumatoid arthritis.Scand J Immunol. 2012 Jul 18. doi: 10.1111/j.1365-3083.2012.02759.x. [Epub ahead of print] PMID: 22809173 (SCI IF 2.230)
16 Deng J, Liu Y, Yang M, Wang S(王胜军), Zhang M, Wang X, Ko KH, Hua Z, Sun L, Cao X, Lu L Leptin exacerbates collagen-induced arthritis via enhancing Th17 cell response. Arthritis Rheum. 2012 Jul 25. doi: 10.1002/art.34637. [Epub ahead of print] PMID: 22833425 (SCI IF 7.866)
17 Tian J, Ma J, Wang S (王胜军,通讯作者), Yan J, Chen J, Tong J, Wu C, Liu Y, Ma B, Mao C, Jiao Z, Shao Q, Lu L, Xu H. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4(+)CD25(+) regulatory T cells and enhances the effector T cell proliferation. Cell Immunol. 2011;270(2):183-187. (SCI IF 2.575)

18 Ma J, Wang S(王胜军,通讯作者), Ma B, Mao C, Tong J, Yang M, Wu C, Jiao Z, Lu L, Xu H. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Letter, 2011,301(2):142-150. (SCI IF 4.864)

19 Wang Kaiwen, Su Zhaoliang, Zhao Yinxia, Sandoghchian Shotorbani Siamak, Jiao Zhijun, Xue Yuan, Yang Heng, Zheng Dong, Liu Yanfang, Shen Pei, Wang Shengjun(王胜军,共同通讯作者), Shao Qixiang, Huang Xinxiang, Lu Liwei, Xu Huaxi . Changes and signiWcance of IL-25 in chicken collagen II-induced experimental arthritis (CIA). Rheumatol Int. 2012 Aug;32(8):2331-8. (SCI IF 1.431)

20 Dawei Cui, Shengjun Wang(王胜军,通讯作者), Yu Chen, Jia Tong, Jie Ma, Li Tang, Xianzhi Yang, Ye Shi , Jie Tian, Liwei Lu, Huaxi Xu. An Isoleucine Zipper Motif Enhances Costimulation of Human Soluble Trimeric GITR ligand. Cell Mol Immunol, 2010,7(4) 316-322. (SCI IF 2.026)

21 Su Z, Kong F, Wang S(王胜军,共同通讯作者), Chen J, Yin R, Zhou C, Zhang Y, He Z, Shi Y, Xue Y, Shi X, Lu L, Shao Q, Xu H. The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer. Eur J Clin Microbiol Infect Dis. 2010, 29(4):429-37. (SCI IF 2.631)

22 Yang P, Qiu G, Wang S(王胜军,共同通讯作者), Su Z, Chen J, Wang S, Kong F, Lu L, Ezaki T, Xu H. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet. 2010, 37(2):111-115. (SCI IF 1.620)

23 Shi Y, Wang H, Su Z, Chen J, Xue Y, Wang S (王胜军,共同通讯作者), Xue Y, He Z, Yang H, Zhou C, Kong F, Liu Y, Yang P, Lu L, Shao Q, Huang X, Xu H.Differentiation Imbalance of Th1/Th17 in Peripheral Blood Mononuclear Cells Might Contribute to Pathogenesis of HT. Scand J Immunol, 2010,72(3):250-255. (SCI IF 1.935)

24 Chen J, Su Z, Liu Y, Sandoghchian S, Zheng D, Wang S(王胜军,共同通讯作者), Xu H. Herbaspirillum Species: A Potential Pathogenic Bacteria Isolated from Acute Lymphoblastic Leukemia Patient. Curr Microbiol. 2010, 62(1):331-333. (SCI IF 1.510)

25 Lam QL, Wang S(王胜军), Ko OK, Kincade PW, Lu L. Leptin signaling maintains B cell homeostasis via induction of Bcl-2 and Cyclin D1. Proc Natl Acad Sci U S A, 2010,107(31): 13812-13817. (SCI IF 9.771)

26 Yang M, Sun L, Wang S(王胜军), Ko KH, Xu H, Zheng BJ, Cao X, Lu L. Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing Regulatory B Cells. J Immunol, 2010, 184(7):3321-3325. (SCI IF 5.745)

27 Wang W, Shao S, Jiao Z, Guo M, Xu H, Wang S(王胜军).The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int. 2011 Jan 11. [Epub ahead of print]PMID: 21221592. (SCI IF 1.431)

28 Jiao Z, Wang W, Xu H, Wang S(王胜军), Guo M, Chen Y, Gao J. Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1. Clin Exp Immunol. 2011; 164(1):66-71. (SCI IF 3.134)

29 Wu C, Wang S(王胜军), Wang F, Chen Q, Peng S, Zhang Y, Qian J, Jin J, Xu H. Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia. Clin Exp Immunol. 2009;158(2): 199-204. (SCI IF 3.134)

30 Chen J, Su Z, Liu Y, Wang S(王胜军), Dai X, Li Y, Peng S, Shao Q, Zhang H, Wen P, Yu J, Huang X, Xu H. Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China. Int J Infect Dis. 2009;13(6):717-721. (SCI IF 2.529)

31 Xu H, Su Z, Wang S(王胜军), Dai X, Chen J, Kong F, Li Y, Peng S, Shao Q, Lu L, Ezaki T. Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china. Curr Microbiol. 2009; 59(2):113-117. (SCI IF 1.510)

32 Lo CK, Lam QL, Yang M, Ko KH, Sun L, Ma R, Wang S(王胜军), Xu H, Tam S, Wu CY, Zheng BJ, Lu L. Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell Mol Immunol. 2009;6(5):353-360. (SCI IF 2.026)

33 Chaoming Mao, Shengjun Wang(王胜军,通讯作者), Qian Jiang, Jia Tong, Jie Ma, Min Yang, Xiaopeng Xu, Gufeng Qiu, Qixiang Shao, Long Li,Huaxi Xu. Increased CD4+CD25+FOXP3+ Regulatory T Cells in Cancer Patients from Conversion of CD4+CD25- T Cells through Tumor-derived Factors. Oncologie, 2008,31(5) 243-248. (SCI IF 1.156)

34 Min YANG, Shengjun WANG(王胜军), Suoying WANG, Qixiang SHAO, Qing DING, Huaxi XU. Tat-mediated intracellular delivery of T-bet protein into THP-1 cells can induce Th1 type response. Immunological Investigations. 2008; 37(2):1-15. (SCI IF 1.270)

35 Lo CK, Lam QL, Sun L, Wang S(王胜军), Ko KH, Xu H, Wu CY, Zheng BJ, Lu L. Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum. 2008;58(9):2700-2711. (SCI IF 8.435)

36 Su Z, Dai X, Chen J, Kong F, Wang H, Li Y, Peng S, Wang S(王胜军), Shao Q, Lv L, Xu H. The bla(CTX-M-1) gene located in a novel complex class I integron bearing an ISCR1 element in Escherichia coli isolates from Zhenjiang, China. J Antimicrob Chemother. 2008;62(5):1150-1151. (SCI IF 4.659)

37 SY Wang, M Yang, XP Xu, GF Qiu, J Ma, SJ Wang(王胜军), XX Huang, HX Xu. Intranasal Delivery of T-bet Modulates the Profi le of Helper T Cell Immune Responses in Experimental Asthma. J Investig Allergol Clin Immunol 2008; 18(5): 357-365. (SCI IF 1.489)

38 Wang SJ(王胜军,通讯作者), Xu HX, Wang YZ, Ma J, Mao CM, Shao QX, Ma B, Xu WR, Yang SL. Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 2006; 18(6): 1193-1200. (SCI IF 1.814)

39 Wang SJ(王胜军,通讯作者), Yao K, Xie FD, Ji XH. Effects of Tripterygium wilfordii saponins and interleukin-10 on dendritic cells from human peripheral blood. Acta pharmacological sinica, 2001;22(8):721-724. (SCI IF 1.909)

40 Wang SJ(王胜军,通讯作者), Xu HX, Liu GZ. Tripterygium wilfordii saponins and interleukin-10 prevent induction of experimental autoimmune thyroiditis by dendritic cells. Acta Pharmacologica Sinica, 2000; 21(10):919-923. (SCI IF 1.909)
(注:SCI IF为论文发表时期刊的影响影子)