许化溪

 
出生年月
 
研究领域
免疫相关性疾病的诊断与治疗研究、生物资源免疫调节作用和疾病的营养干预、细菌基因诊断与致病性研究
 
主讲课程
医学免疫学(临床医学本科),病原生物学(临床医学本科),临床免疫学及免疫检验(医学检验本科),临床微生物学检验(医学检验本科),现代免疫学(医学硕士),新发传染病(医学硕士),临床免疫学(医学硕士),微生物工程(食品科学博士),免疫学进展(医学博士)
 
个人简介

许化溪,男,教授,医学博士,博士生导师,现任江苏大学党委副书记、纪委书记,基础医学与医学技术学院检验医学研究所第一所长。1981年毕业于镇江医学院;1983年-1984年在浙江医科大学微生物学高师班学习;1990年毕业于大连医科大学,获医学硕士学位;1998-2000年留学于日本岐阜大学医学部,获医学博士学位。2009年7月至9月在美国路易斯威尔大学做高级访问学者。历任镇江医学院医学检验系副主任、主任,药学系主任(兼),1997年10月任镇江医学院副院长,2001年8月任江苏大学副校长,基础医学与医学技术学院检验医学研究所所长,2012年任江苏大学党委副书记、纪委书记,基础医学与医学技术学院检验医学研究所第一所长。先后入选首批江苏省“333”工程二层次、江苏省普通高校优秀青年骨干教师、江苏省高校跨世纪学科带头人选、江苏省重点学科临床检验诊断学学科带头人,享受国务院政府特殊津贴,曾获江苏省普通高等学校“红杉树”园丁奖银奖。

 
学术简介

长期从事医学微生物学与免疫学、检验医学的教学和研究工作。在基于转录因子的免疫相关性疾病干预研究、树突状细胞免疫功能研究、单克隆抗体的研制及单抗人源化研究、生物资源免疫调节作用和疾病的营养干预、细菌基因诊断与致病性研究、微生物资源利用与微生物功能因子研究等方面形成了独特的研究方向。主持完成国家自然科学基金资助的研究课题6项、省部级课题3项、省教育厅和卫生厅课题多项,主持完成“863”项目子课题1项;参与十一•五国家科技支撑计划1项、参与或指导研究生承担的国家自然科学基金8项。先后在国内外学术刊物发表论文100余篇,出版教材和专著20余部。关于“淋巴树状突细胞的实验研究”及“树突状细胞与免疫相关性疾病关系的研究”等科研成果,分别获得省、部级科技进步二、三等奖6项,江苏省医学科技进步二等奖3项。获江苏省优秀教学成果一等奖1项,江苏省优秀课程群和精品课程各1项。

担任中国免疫学会理事、中国微生物学会理事、江苏省免疫学会副理事长、中华医学会江苏省微生物学和免疫学会副主任委员、江苏省医学会理事、美国免疫学会会员、全国高等医药教材建设研究会理事及卫生部教材评审委员会委员。

 
主要科研项目成果

成果:
1.淋巴树突状细胞的实验研究. 江苏省科技进步三等奖. 1993年.(3/12)
2. 鼠树突状细胞的研究. 铁道部科技进步二等奖.1994年.(3/12)
3. 树突状细胞单克隆抗体的研制及其初步应用研究.江苏省卫生厅科技进步二等奖,1997年.(1/7)
4.自身免疫性甲状腺炎的实验及临床研究.全军科技进步三等奖.2001.(3/5)。
5.造血干细胞分离保存和血小板活化因子分析测定及临床应用.江苏省科技进步三等奖. 镇江市科技进步一等奖. 2004.(4/5)
6.树突状细胞与免疫相关性疾病关系的研究.江苏省科技进步三等奖. 1998.(1/5); 江苏省卫生新技术引进二等奖.2009.(3/5).
7.间质干细胞分化及致瘤安全性研究.教育部自然科学奖二等奖(2009). (7/9).
8.关于细菌遗传学相似度检测的方法学研究. 通过江苏省科技厅成果鉴定(2005).获得镇江市科技进步二等奖. 2006. 江苏省卫生新技术引进二等奖.2010.(1/5)
9.革兰阴性菌整合子耐药机制研究.镇江市科技进步二等奖、江苏省卫生新技术引进二等奖.2009(3/5)
主要研究论文:
1.The blaCTX-M-1gene located in a novel complex classI integron bearing an ISCR1 element in E. coli isolates from Zhenjiang, China. J Antimicrob Chemother. 2008 Jul 21.
2.Tat-mediated Intracellular Delivery of T-bet Protein into THP-1 Cells can Induce Th1-Type Response. Immunological Investigations,2008;37:97 –111
3.Intranasal delivery of T-bet gene modulates the profile of T helper cell immune responses in a mouse model of allergic asthma. J Investig Allergol Clin Immunol, Vol 18 (5) :357-65, 2008
4.Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25-T cells through tumor-derived factors. Onkologie. 2008;31 (5) :243-8.
5.Transcriptional expression of fljB:z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses. New Microbiol. 2008;31(2):241-7.
6.Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum. 2008;58 (9):2700-11.
7.Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest. J Microbiol. 2007;45(5):441-6.
8.Avian Influenza: Should China Be Alarmed? Yonsei Medical Journal, 2007 Aug 31;48(4):586-94
9.Mutations in Helicobacter pylori porD and oorD Genes May Contribute to Furazolidone Resistance. Croat Med J. 2006;47(3):410-5.
10.Regulatory T cells induced by rAAV carrying the forkhead boxP3gene prevent autoimmune thyroiditis in mice. Int J Mol Med. 2006;18(6):1193-9.
11.Virulence-defective strains of Salmonella enterica serovar Typhi as candidates for education at level 2 facilities. Microbiol Immunol. 2006;50(4):273-9.
12.Tripterygium wilfordii saponins and interleukin-10 prevent induction of experimental autoimmune thyroiditis by dendritic cells. Acta Pharmacol Sin 2000;21(10):919-23.
13.A rapid method for determining the G+C content of bacterial chromosomes by monitoring fluorescence intensity during DNA denaturation in a capillary tube. Int J Syst Evol Microbiol 2000;50:1463-9.
14.I-ceuI fragment analysis of the shigella species: evidence for large-scale chromosome rearrangement in S. dysenteriae and S. flexneri. FEMS Microbiol Lett. 2000 15;185(2):267.
15.Corynebacterium pyruviciproducens sp. Nov. Producing pyruvic acid. Int J Syst Evol Microbiol. 2010; 60:1135-1140
16.Global transcriptional response of Salmonella enterica serovar Typhi to anti-z66
antiserum.FEMS Microbiol Lett. 2009;298(1):51-5.
17. DNMT3B Promoter Polymorphism and Risk of Gastric Cancer. Dig Dis Sci. 2010;55(4):1011-6
18. Four novel resistance integron gene-cassette occurrences in bacterial isolates from
zhenjiang, china. Curr Microbiol. 2009;59(2):113-7.
19. Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in
Salmonella enterica serovar Typhi. Microbiol Immunol. 2009;53(4):191-7.
20. Identification and characterization of class 1 integrons among Pseudomonas
aeruginosa isolates from patients in Zhenjiang, China. Int J Infect Dis. 2009;13:717-21
21. Serum proteome alteration of severe sepsis in the treatment of continuous renal
replacement therapy. Nephrol Dial Transplant. 2009; 24:3108-3114
22. Immunosuppressive effects of mesenchymal stem cells in collagen-induced mouse
Arthritis. Inflamm.Res, 2009;59(3):219-25.
23.Increased frequencies of T helper type 17 cells in the peripheral blood of patients
with acute myeloid leukaemia 2009, Clinical and Experimental Immunology, 158: 199–204
24. The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer. Eur J Clin Microbiol Infect Dis (2010) 29:429–437
25. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol. 2010; 1;184(7):3321-5
26. The mutations of Th1 cell-specific T-box transcription factor may be
associated with a predominant Th2 phenotype in gastric cancers. 2010; 37:111–115
27. Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. Journal of Clinical Virology 2010; 49:100–104
28. Methyl jasmonate enhances biocontrol ef.cacy of Rhodotorula glutinis to postharvest blue mold decay of pears. Food Chemistry. 2009;117:621–626
29. Salicylic acid enhances biocontrol efficacy of Rhodotorula glutinis against postharvest Rhizopus rot of strawberries and the possible mechanisms involved. Food Chemistry. 2010; 122 577–583
30. An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand. Cell Mol Immunol. 2010;7(4):316-22.
31. Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell Mol Immunol. 2009;6(5):353-60.
32. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4(+)CD25(+) regulatory T cells and enhances the effector T cell proliferation. Cell Immunol. 2011;270(2):183-7
33. Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA). Rheumatol Int. 2011 May 29.
34. Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr Microbiol. 2011;63(1):22-31.
35. Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction on elderly patients with acute kidney injury. Aging Clin Exp Res. 2011 Apr 4.
36. Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples. Anaerobe. 2011;17(2):64-8
37. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int. 2011 Jan 11.
38. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Lett. 2011 Feb 28;301(2):142-50.
37. Mesenchymal stem cells isolated from human uterine cervix cancer tissues. Cell Biol Int. 2011;35(2):119-23
38. RpoE may promote flagellar gene expression in Salmonella enterica serovar typhi under hyperosmotic stress. Curr Microbiol. 2011;62(2):492-500.
39. Herbaspirillum species: a potential pathogenic bacteria isolated from acute lymphoblastic leukemia patient. Curr Microbiol. 2011;62(1):331-3.
40. Immunologic mapping of glycomes: implications for cancer diagnosis and therapy. Front Biosci (Schol Ed). 2011;3:1520-32

 
主要论著

著作:
1.现代医学免疫学 (第二主编)2001 江苏科技出版社
2.Molecular Ecological Detection and Identification of Intestinal Microflora (参编)2001 Japan Scientific Societies Press, Tokyo
3.现代免疫学实验技术(国家重点图书项目)参编,2002湖北科技出版社
4.病原生物学检验――理论与临床 主编,2003年,人民卫生出版社
5.医学免疫学 参编 2001年,人民卫生出版社
6.医学微生物学 参编 2004年,2009年,高等教育出版社
7.临床免疫学和免疫学检验 参编 2003年,2008年 人民卫生出版社
8.现代免疫学 主编,2011年 江苏科技出版社